Mission Statement

APPREMED is a non-profit research organization active in the field of preventive medicine (Belgian registration number: 0739849385). APPREMED has as mission to develop new strategies to prevent chronic age-related disorders in people, who do not yet have any symptoms, but who based on their clinical characteristics and biomarkers (e.g., the urinary proteome), have a high risk of developing target organ damage and thus becoming a “patient”. 


Board Members

Jan A. Staessen, MD, PhD, Mechelen, Belgium

 Prof Jan A Staessen is Emeritus Professor of Medicine at the University of Leuven, where he led the Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences. He was former Head of Clinic at the Division of Cardiology, University Hospitals at the University Hospitals Leuven. In addition, until 2014, he was Professor of Genetic Epidemiology at the Department of Epidemiology, Maastricht University, The Netherlands.

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In 2007, JA Staessen received the title of Doctor Honoris Causa from the Jagiellonian University, Kraków, Poland (JU [P12]), one of the oldest and most prestigious universities in Europe. He is Honorary Professor at the Universidad de la República, Montevideo, Uruguay and at Hospital Italiano, affiliated with the University of Buenos Aires, Argentina. He is visiting professor at Lu He Hospital affiliated with the Capital Medical University, Beijing, China, and at the Shanghai Institute of Hypertension affiliated with Shanghai Jiao Tong University School of Medicine. He is honorary member of the Czech, Polish and Spanish Societies of Hypertension. He received an ERC Advanced Researcher Grant for population-based research on left ventricular diastolic dysfunction (EPLORE-294713) and a Proof-of-Concept Grant (uPROPHET-713601) applying EPLORE findings in heart transplant recipients.  JA Staessen is currently affiliated with Mosaiques-Diagnostic GmbH, Hannover, Germany. 

JA Staessen published over 1400 papers in peer-reviewed journals, 210 as first author and over 490 as second last or last author.  Currently, his citation index (excluding own citations) is 85,954 (average number of citations per publication, 61.4) and his H-index is 124 (Scopus – 2022-03-28).  Dr Staessen serves on the editorial board of several top-ranking medical journals.  He was Associate Editor of Hypertension from 2007 until 2022.  He is Guest Editor of Circulation and Hypertension Research, the official journal of the Japanese Society of Hypertension.  He serves on the Editorial Board of the American Journal of Hypertension, the Circulation Journal, the official journal of the Japanese College of Cardiology, and Arterial Hypertension, the official journal of the Polish Society of Hypertension.  He is advisor to The Lancet.  Dr Staessen is currently vice-chair of the Scientific Advisory Group Cardiovascular Medicine, European Medicines Agency.


Tine Willum Hanssen, MD, PhD, Copenhagen, Denmark

PhD Tine Willum Hansen (female) is senior researcher at Steno Diabetes Center Copenhagen, Denmark. She is specialized in clinical physiology and nuclear medicine and one of her main interest is the evolving role of cardiac imaging as a tool in investigating cardiovascular risk, structure and function. She has wide experience in clinical research.

Prof. Tine W. HansenTine Willum Hansen published 127 papers in peer-reviewed journals. Currently, her citation index is 9,076 and her H-index 39 (Web of Science – 2020-03-07). Tine Willum Hansen serves on the editorial board of Hypertension, Artery Research, American Journal of Hypertension and Journal of Clinical Hypertension. She is executive committee member of The Association for Research into Arterial Structure and Physiology (ARTERY) and was chair of Local Organizing Committee of the ARTERY 16 meeting held in Copenhagen, 2016.



Gladys E. Maestre, MD, PhD, Rancho Viejo, Texas, US

Gladys E. Maestre is Professor of Neuroscience and Human Genetics and the Director of the Rio Grande Valley Alzheimer’s Disease Resource Center for Minority Aging Research (AD-RCMAR) at the University of Texas Rio Grande Valley School of Medicine.  Professor Emerita at the University of Zulia at Venezuela.  She received her M.D. from the University of Zulia in Venezuela and her M.Phil. and Ph.D. from Columbia University, and post-doctoral training in the Department of Psychiatry at the Massachusetts General Hospital.

Gladys E Maestre 2Gladys E. Maestre leads the Maracaibo Aging Study as principal investigator since 1998. This is a longitudinal population-based study of dementia and other age-related health problems that has followed more than 2,500 subjects since its inception and has provided important insights about the aging of Latinos. Recipient of numerous awards, and recognized author, the focus of her research is to advance age-related conditions that disproportionately affect Latinos, at the intersection of biomedical, social and behavioral, and implementation sciences.



Kei Asayama, MD, PhD, Tokyo, Japan

Dr. Kei Asayama is an Associate Professor of the Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.  K Asayama received his MD in 2001 and his PhD in 2005 from Tohoku University, Sendai, Japan.  Following his clinical and research activities in the same university, he underwent a fellowship at the University of Leuven in Belgium from 2011 to 2014.  In 2016, he received the Established Investigator Award from the Japanese Society of Hypertension.

K Asayama is a member of several professional societies, including the International Society of Hypertension, the European Society of Hypertension, and the American Heart Association.  He is a council member and fellow of the Japanese Society of Hypertension and the Council of the Japanese Society of Cardiovascular Disease Prevention, and is an ISO/TC121 committee member of the Japan Association of Medical Equipment Industries.  
Research interests of K Asayama focus on cardiovascular epidemiology, in particular hypertension.  He is a project manager of the multicenter HOMED-BP (Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure) study.  In respect to APPREMED activities, he contributes to individual participant-data meta-analyses on IDACO (International Database on Ambulatory blood pressure monitoring in relation to Cardiovascular Outcome) and IDHOCO (International Database of HOme blood pressure in relation to Cardiovascular Outcome).



Katarzyna Stolarz-Skrzypek, MD, PhD, Kraków, Poland 

KSS-photo Prof. Katarzyna Stolarz-Skrzypek is a Professor at the First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College in Krakow, Poland. She is a specialist in cardiology, arterial hypertension and internal medicine. Since 2021 she has been appointed as the Director of the Doctoral School of Medical and Health Sciences at the Jagiellonian University.  Her main scientific interests include role of genetic and environmental factors in the development of hypertension and cardiovascular disease, blood pressure and heart rate variability and white-coat and masked hypertension. Prof. Stolarz-Skrzypek was a visiting scientist at the University of Leuven, Belgium, from 2001 to 2003 and from 2009 to 2010. Prof. Stolarz-Skrzypek is an editorial board member of Hypertension Research, Blood Pressure, Kardiologia Polska-Polish Heart Journal. She was a co-chair of the Satellite Symposium to the Annual Meeting of the European Society of Hypertension organized in Krakow in 2023.





APPREMED received a non-binding grant from OMRON Healtcare Ltd., Inc., Kyoto, Japan. 


Data Sharing

Scientifically motivated requests for data sharing (FLEMENGHO, IDACO, IDHOCO or IDCARS) should be addressed to Prof JA Staessen along with a 2-page document describing the hypothesis, the statistical analysis plan and the expected outcomes.



APPREMED is located at Leopoldstraat 59, BE-2800 Mechelen, Belgium.

Telephone: +32 47 632 4928 (cell phone)

Fax: +32 15 41 4542

URL: https://www.appremed.org

Primary email: jan.staessen@appremed.org

Twitter: @jasta49